Abstract: "This study included 27,670 participants (mean baseline age 58.1 years, SD 7.6; 61% female). During a median of 25 years of follow-up, 3,208 incident dementia cases were recorded. Consumption of ≥50 g/d of high-fat cheese (>20% fat) was associated with a reduced risk of all-cause dementia (HR 0.87; 95% CI, 0.78–0.97) and VaD (HR 0.71, 95% CI 0.52–0.96) compared with lower intake (<15 g/d). An inverse association between high-fat cheese and AD was found among APOE ε4 noncarriers (HR 0.87, 95% CI 0.76–0.99, p-interaction = 0.014). Compared with no consumption, individuals consuming ≥20 g/d of high-fat cream (>30% fat) had a 16% lower risk of all-cause dementia (HR 0.84, 95% CI 0.72–0.98). High-fat cream consumption was inversely associated with the risk of AD and VaD. Consumption of low-fat cheese, low-fat cream, milk (high-fat and low-fat), fermented milk (high-fat and low-fat), and butter showed no association with all-cause dementia."
A hundred bucks says the correlation goes away if you control for factors that are likely a shared root cause for dementia and avoiding high fat dairy. Such as trying to control pre-existing obesity or high cholesterol.
> Body mass index (BMI) was calculated from measured weight and height and categorized into 4 groups (<18.5, 18.5–24.9, 25–29.9, and ≥30 kg/m2). Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg, or the use of antihypertensive medication. Diabetes was identified through self-reported diagnosis, medication usage, and registry records. The intake of lipid-lowering drugs was self-reported. Baseline blood lipoproteins were only available in 4,549 participants and, therefore, not included as covariates. The APOE genotype was determined based on 2 single-nucleotide variants, rs429358 and rs7412, which define the ε2, ε3, and ε4 alleles. Participants carrying at least 1 ε4 allele were classified as APOE ε4 carriers.
Original article: "High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia" - https://www.neurology.org/doi/10.1212/WNL.0000000000214343?u...
Abstract: "This study included 27,670 participants (mean baseline age 58.1 years, SD 7.6; 61% female). During a median of 25 years of follow-up, 3,208 incident dementia cases were recorded. Consumption of ≥50 g/d of high-fat cheese (>20% fat) was associated with a reduced risk of all-cause dementia (HR 0.87; 95% CI, 0.78–0.97) and VaD (HR 0.71, 95% CI 0.52–0.96) compared with lower intake (<15 g/d). An inverse association between high-fat cheese and AD was found among APOE ε4 noncarriers (HR 0.87, 95% CI 0.76–0.99, p-interaction = 0.014). Compared with no consumption, individuals consuming ≥20 g/d of high-fat cream (>30% fat) had a 16% lower risk of all-cause dementia (HR 0.84, 95% CI 0.72–0.98). High-fat cream consumption was inversely associated with the risk of AD and VaD. Consumption of low-fat cheese, low-fat cream, milk (high-fat and low-fat), fermented milk (high-fat and low-fat), and butter showed no association with all-cause dementia."
A hundred bucks says the correlation goes away if you control for factors that are likely a shared root cause for dementia and avoiding high fat dairy. Such as trying to control pre-existing obesity or high cholesterol.
They did in fact control for these factors.
> Body mass index (BMI) was calculated from measured weight and height and categorized into 4 groups (<18.5, 18.5–24.9, 25–29.9, and ≥30 kg/m2). Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg, or the use of antihypertensive medication. Diabetes was identified through self-reported diagnosis, medication usage, and registry records. The intake of lipid-lowering drugs was self-reported. Baseline blood lipoproteins were only available in 4,549 participants and, therefore, not included as covariates. The APOE genotype was determined based on 2 single-nucleotide variants, rs429358 and rs7412, which define the ε2, ε3, and ε4 alleles. Participants carrying at least 1 ε4 allele were classified as APOE ε4 carriers.
Depression correlates with dementia. As do many drugs to treat various psychiatric conditions
What’s your favorite school of mental gymnastics?
Blessed are the cheese makers.
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